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. 2019 Jun 5;10(6):438. doi: 10.1038/s41419-019-1683-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — In the presence of Rbpj (with Rbpj), Rbpj regulates the expression of Vcam1 in the allantois through a Notch-dependent manner to ensure normal chorioallantoic branching morphogenesis, and facilitated Mash2 in EPC (Sp) to promote the specification of Tpbpα-positive trophoblast cells simultaneously. However, failed chorioallantoic branching and defective trophoblast differentiation in EPC (Sp) were observed in the absence of Rbpj (without Rbpj). Dec decidual basalis, Sp spongiotrophoblast layer, SPA spiral arteries