Table 2.
Univariate and multivariate Cox analysis of OS in the training cohort (n = 352)
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Sex (female/male) | 0.934 (0.611, 1.428) | 0.75 | ||
| Age, years | 1.007 (0.991, 1.024) | 0.38 | ||
| HBsAg (yes/no) | 0.915 (0.590, 1.419) | 0.69 | ||
| HBcAb (yes/no) | 0.664 (0.405, 1.088) | 0.12 | ||
| Anti-HCV (yes/no) | 1.671 (0.234, 11.951) | 0.61 | ||
| Bilirubin, μmol/L | 0.987 (0.961, 1.014) | 0.36 | ||
| ALT, IU/L | 1.002 (1.000, 1.004) | 0.12 | ||
| Albumin, g/L | 0.738 (0.526, 1.035) | 0.08 | ||
| AFP, ng/mL | 1.000 (1.000, 1.000) | 0.19 | ||
| GGT, U/L | 1.002 (1.001, 1.004) | < 0.001 | 1.002 (1.000, 1.004) | 0.01 |
| Liver cirrhosis (yes/no) | 1.461 (0.919, 2.319) | 0.11 | ||
| Tumor diameter, cm | 1.153 (1.107, 1.202) | < 0.001 | 1.100 (1.046, 1.156) | < 0.001 |
| Tumor number | 1.259 (1.004, 1.583) | 0.046 | 1.266 (0.976, 1.643) | 0.08 |
| Microvascular invasion (yes/no) | 1.362 (1.065, 1.767) | 0.02 | 1.211 (0.995, 1.599) | 0.09 |
| Lymphoid metastasis (yes/no) | 1.833 (0.256, 13.108) | 0.55 | ||
| Tumor differentiation (Edmondson-Steiner grade I-II/III-IV) | 1.753 (1.232, 2.494) | 0.002 | 1.819 (1.268, 2.610) | 0.001 |
| Occlusion time, min | 1.028 (1.011, 1.045) | < 0.001 | 1.013 (0.996, 1.031) | 0.14 |
| TRIS | 12.197 (3.835, 38.791) | < 0.001 | 4.606 (1.335, 15.89) | 0.02 |
HBsAg hepatitis B surface antigen, HBcAb hepatitis B core antibody, HCV hepatitis C virus, AFP α-fetoprotein, ALT alanine aminotransferase, GGT γ-glutamyl transferase, AFP alpha fetoprotein, TRIS tissue-related immune signature