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Diagnostic performance of mNGS compared with culture and Alere BinaxNow® Streptococcus pneumoniae Antigen test for the detection of Streptococcus pneumoniae
| Clinical microbiology tests | mNGS | |||
|---|---|---|---|---|
| Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | |
| Culturea | 73.1 | 88.1 | 59.4 | 93.2 |
| Combined testb | 70.3 | 93.9 | 81.3 | 89.3 |
Note: arefers to the blood and/or CSF culture; brefers to culture and or Alere BinaxNow® Streptococcus pneumoniae Antigen test. PPV positive predictive value, NPV negative predictive value
