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. 2019 May 29;10:979. doi: 10.3389/fimmu.2019.00979

Figure 2.

Figure 2

AS101 and SAS inhibit in vitro the activity of the α4β7 integrin in various organs of NOD mice. 5 × 105 single cells from spleens (A), peripheral LN (B), and PLN (C) from 10 week old NOD mice were cultured on BSA or MAdCAM-1-coated micro wells for 2 h in the presence or absence of different concentrations of SAS or AS101The cells were washed twice and then subjected to XTT reagent according to the manufacturer's instructions. The results represent means±SE of three different experiments. *p < 0.001 decrease vs. MAdCAM-1 without AS101 or SAS (SAS 0).