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. 2019 May 29;10:979. doi: 10.3389/fimmu.2019.00979

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Copyright © 2019 Yossipof, Bazak, Kenigsbuch-Sredni, Caspi, Kalechman and Sredni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AS101 and SAS prevent islet damage and preserve islet function. (A)AS101 or SAS at 1 mg/kg/injection were administered i.p. every other day to female NOD mice, starting at 3 weeks of age. At 20 weeks, pancreatic heads were fixed and stained for insulin (red), glucagon (green), and nuclear staining (blue). Pancreata from 5 week old mice (pre-diabetic) served as a control. (a) Pre-diabetic; (b) PBS; (c) AS101; (d) SAS. The results are representative of 3 mice/group. 10 slides/mouse were visualized. X400. (B) Microscopic determination of islet radius. Results represent means ± SE of 5 mice/group. ^*p < 0.01 vs PBS. (C) Pancreas cell lysates from 20w old mice were analyzed for caspase-3 activity by colorimetric assay. Results represent means ± SE of 5 mice/group. ^*p < 0.01 vs. all groups.