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. 2019 May 29;14:3995–4005. doi: 10.2147/IJN.S200909

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© 2019 Abdulqadir and Aziz.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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Internalization of NiNPs into the interstitial region of kidney cortex: (A) control group showing interstitial region between two proximal convoluted tubules. (B and C) the NiNP-treated group showing (B) deposition of NiNPs close to membranes (arrows), and (C) number of electron dense particles within vacuole close to the PT basement membrane (arrow).

Abbreviations: PT, proximal convoluted tubule; NiNPs, nickel nanoparticles; BM, basement membrane; In, interstitial region; M, mitochondria.