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. 2019 May 29;14:3995–4005. doi: 10.2147/IJN.S200909

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© 2019 Abdulqadir and Aziz.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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Ultrastructure changes in podocytes and mesangial cells in NiNP-treated rat kidney. (A) Degeneration of podocytes showing the fusion of foot processes (effacement) (arrows). Mesangial cells appeared degenerated having fragmented nucleus (black arrows). Neutrophil in the blood capillary showing phagocytosis of the degenerating mesangial cells. (B) Enlargement of (A) showing the phagocytosis process and engulfing of apoptotic bodies of mesangial cells and fusion of foot processes of podocytes.

Note: P₁, primary podocyte foot processes; P₂, secondary podocyte foot processes.

Abbreviations: NiNPs, nickel nanoparticles; P, podocytes; RBC, red blood cells; BC, blood capillary; MC, mesangial cells; Npl, neutrophil; ap, apoptotic bodies.