Table 3.
Univariate and multivariate binomial logistic regression analyses describing the associations between pSS molecular markers, patient characteristics and anti-EA positivity in ASSESS patients.
| Anti-EA IgG positivity | ||||||
|---|---|---|---|---|---|---|
| Univariate analyses | Multivariate analyses | |||||
| OR | [95% CI] | P-value | OR | [95% CI] | P-value | |
| Sex (Women vs. Men) | 1.74 | 0.67–4.54 | 0.25 | |||
| Age over 50 y/o | 1.10 | 0.67–1.82 | 0.7 | |||
| Anti-SSA positive alone | 1.54 | 0.89–2.65 | 0.12 | 1.07 | 0.59–1.92 | 0.83 |
| Anti-SSA/B positivity | 2.41 | 1.44–4.02 | 0.0008 | 1.32 | 0.71–2.45 | 0.37 |
| Beta 2 microglobulin > 2.5 mg/L | 3.05 | 1.89–4.91 | < 0.0001 | 2.56 | 1.50–4.37 | 0.0006 |
| Total IgG level >16.0 g/L | 2.23 | 1.39–3.55 | 0.0008 | 1.49 | 0.85–2.62 | 0.16 |
| Kappa/Lambda light chain ratio > 1.65 | 1.16 | 0.50–2.69 | 0.73 | |||
| Total Kappa and Lambda > 45.7 mg/L | 2.70 | 1.52–4.81 | 0.0007 | |||
Numbers in bold, significant associations. Variables having P < 0.2 in univariate analysis were included in multivariate model. Ant-SSA/B, anti Sjögren's syndrome antibody A and B; IgG, immunoglobulin G.