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. 2019 Jun 5;2019(6):CD009670. doi: 10.1002/14651858.CD009670.pub4

Begh 2015.

Methods Setting: NHS Stop Smoking clinic, UK
Recruitment: smokers recruited from the participating general practices and Stop Smoking services. Selected for motivation to quit
Participants 119 smokers; 69% female; average age 44.8; average cigarettes smoked per day 20.8
Therapists: trained research nurses and Stop Smoking advisors
Interventions Pharmacotherapy: NRT; 21 mg per 24 hour nicotine patches for 8 to 12 weeks
1. 7 weekly sessions of withdrawal support, of which 5 sessions included placebo training (16 minutes each) starting one week prior to quit date
2. 7 weekly sessions of withdrawal support, of which 5 sessions included attentional retraining (16 minutes each) starting one week prior to quit date
Outcomes Prolonged abstinence at weeks 4, 8, and at 6 months
Validation: exhaled carbon monoxide < 10 ppm
Source of Funding/CoI National Institute for Health Research. Authors declared research and consultancy for manufacturers of smoking cessation medication, including consultancy for GlaxoSmithKline Consumer Healthcare and research‐initiated project grant funding from Pfizer.
Notes New for 2019 update
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated simple randomisation scheme
Allocation concealment (selection bias) Low risk An independent programmer entered the sequence onto a dedicated online database which was accessed by study staff in clinics
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk Biochemically validated
Incomplete outcome data (attrition bias) 
 All outcomes Low risk 30.0% to 40.7% lost to follow‐up at 6 months