Begh 2015.
Methods | Setting: NHS Stop Smoking clinic, UK Recruitment: smokers recruited from the participating general practices and Stop Smoking services. Selected for motivation to quit |
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Participants | 119 smokers; 69% female; average age 44.8; average cigarettes smoked per day 20.8 Therapists: trained research nurses and Stop Smoking advisors |
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Interventions | Pharmacotherapy: NRT; 21 mg per 24 hour nicotine patches for 8 to 12 weeks 1. 7 weekly sessions of withdrawal support, of which 5 sessions included placebo training (16 minutes each) starting one week prior to quit date 2. 7 weekly sessions of withdrawal support, of which 5 sessions included attentional retraining (16 minutes each) starting one week prior to quit date |
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Outcomes | Prolonged abstinence at weeks 4, 8, and at 6 months Validation: exhaled carbon monoxide < 10 ppm |
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Source of Funding/CoI | National Institute for Health Research. Authors declared research and consultancy for manufacturers of smoking cessation medication, including consultancy for GlaxoSmithKline Consumer Healthcare and research‐initiated project grant funding from Pfizer. | |
Notes | New for 2019 update | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Computer‐generated simple randomisation scheme |
Allocation concealment (selection bias) | Low risk | An independent programmer entered the sequence onto a dedicated online database which was accessed by study staff in clinics |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Biochemically validated |
Incomplete outcome data (attrition bias) All outcomes | Low risk | 30.0% to 40.7% lost to follow‐up at 6 months |