Hall 1998.

Methods	Setting: cessation clinic, USA Recruitment: community volunteers. Exclusion criteria included MDD within 3 m of baseline
Participants	199 smokers of ≥ 10 cpd; 55% F, av age 40, av cpd 21‐25; 33% had history of MDD Therapists: 3 doctoral‐level clinical psychologists
Interventions	Pharmacotherapy: nortriptyline (titrated to therapeutic levels ‐ usually 75‐100 mg/day for 12 wks). Placebo arms of factorial trial not used in review 1. Mood management. 10 x 2 hr sessions over 8 wks 2. Standard group therapy control. 5 x 90 min sessions over 8 wks (see Hall 1994 for description of each intervention)
Outcomes	Abstinence at 64 wks (1 yr post‐treatment). Continuous abstinence rates not reported by psychological treatment group Validation: CO < 10 ppm and cotinine < 341 nmol/L
Source of Funding/CoI	National Institute on Drug Abuse. No declarations of interest
Notes	Both behavioural interventions were relatively intensive.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomised by computer, after stratification on history of MDD and number of cigs smoked
Allocation concealment (selection bias)	Low risk	Computer randomisation after data collection
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Biochemically validated
Incomplete outcome data (attrition bias) All outcomes	Low risk	16% lost to follow‐up at 1 yr, no difference by group, included in denominators for MA