Humfleet 2013.

Methods	Setting: HIV clinics, USA Health Care Recruitment: HIV clinic patients, volunteering for study
Participants	209 smokers 82% M, av age 45, av cpd 20 Therapists: clinicians specialising in smoking cessation/social work/psychology
Interventions	Pharmacotherapy: NRT; patch or gum for 10 weeks, available to those who smoked ≥ 5 cpd, number not eligible, not specified 1. Self help: "How to Quit Smoking"; brief meeting with study staff who reviewed guide and recommended establishing a quit date 2. Individual counselling: 6 x 40 to 60‐min sessions of CBT targeted towards needs of HIV positive smokers, weeks 1, 2, 3, 4, 8 & 12 3. Computer‐based: each component structured into a “step” roughly corresponding to the first 5 sessions of the counselling intervention. Individuals were directed to complete self‐assessment exercises and homework assignments.
Outcomes	Abstinence at 52 weeks (7‐day PP) Validation: CO ≤ 10 ppm
Source of Funding/CoI	National Institute on Drug Abuse. California Tobacco‐Related Disease Research Program. Authors declared no conflicts of interest.
Notes	Individual counselling compared to self‐help in main MA, added computer‐based arm in sensitivity analysis
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Smokers stratified based on N cpd, gender, history of depression and then within each stratum randomised via computer algorithm to 1 of 3 conditions in 1:1:1 fashion into a parallel‐group design
Allocation concealment (selection bias)	Low risk	Randomisation occurred after enrolment & stratification.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Biochemically validated
Incomplete outcome data (attrition bias) All outcomes	Low risk	19% overall loss to follow‐up