Reid 1999.

Methods	Setting: community, Canada Recruitment: volunteers
Participants	396 smokers interested in quitting within 30 days, smoking ≥ 15 cpd; 48% F, av age 38, av cpd 23 to 24
Interventions	Pharmacotherapy: NRT; patch (15 mg x 8 wks, 10 mg x 2 weeks, 5 mg x 2 weeks) free 1. Physician advice (3 x 15‐min, 2 weeks before, 4 weeks, 12 weeks after quit date) 2. As 1, plus telephone calls from nurse counsellors, x 3 at 2, 6, 13 weeks
Outcomes	Abstinence at 12 m (PP) Validation: CO, but self‐reported rates reported. Only 1 disconfirmation
Source of Funding/CoI	National Cancer Institute of Canada with funds from the Canadian Cancer Society Nicotine replacement therapy was provided at no cost by McNeil Consumer Products. "The University of Ottawa Heart Institute Research Corporation has a contract with Johnson & Johnson–Merck Consumer Pharmaceuticals to manage the 'Stop Smoking Now!' telephone counselling service offered to users of Nicotrol NRT. The authors received a grant from Johnson & Johnson–Merck to conduct a pilot study before the clinical trial; no payment was received from the company for the clinical trial or its analysis and write‐up."
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Randomised using table of random numbers, stratified by sex and nicotine dependence
Allocation concealment (selection bias)	Unclear risk	Concealment unclear but physician blind to allocation
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Biochemically validated
Incomplete outcome data (attrition bias) All outcomes	Low risk	84% intervention, 86% control, followed up at 12 m