Rovina 2009.

Methods	Setting: smoking cessation clinic, Greece Recruitment: clinic attenders invited to participate
Participants	205 smokers
Interventions	Pharmacotherapy: bupropion 300 mg/day for 19 weeks 1. Control: 15 mins physician counselling 2. Nonspecific group therapy (NSGT), 1‐hour weekly for 1 month, then every 3 weeks until 19 weeks 3. Cognitive behavioral group therapy (CBGT), same schedule 4. CBGT without bupropion ‐ not used in review
Outcomes	Abstinence at 12 months after end of treatment (continuous) Validation: CO ≤ 10 ppm
Source of Funding/CoI	No source of funding reported. Authors declared no conflicts of interest.
Notes	2 & 3 vs 1 in primary analysis, same intensity
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Randomised, method not stated, 3:1:1:1 ratio
Allocation concealment (selection bias)	Unclear risk	No details reported
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Biochemically validated
Incomplete outcome data (attrition bias) All outcomes	Low risk	90% followed up at 12 months