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. 2019 May 29;10:1193. doi: 10.3389/fimmu.2019.01193

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Copyright © 2019 Lisco, Wong, Price, Ye, Niemela, Anderson, Richards, Manion, Mystakelis, Similuk, Lo, Stoddard, Rosenzweig, Vanpouille, Rupert, Maric, Perez-Diez, Parenti, Burbelo, Rao and Sereti.

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Circulating T follicular helper cells (cTfh) and theirs subpopulation in health subjects (blue square), ALPS-FAS subjects irrespective of CD4 cell counts (red circles), ALPS-FAS with CD4 lymphopenia (orange diamond), and ALPS-FAS without CD4 lymphopenia (green hexagon). ^*Comparisons with statistically significant differences. (A) Proportion of total cTfh cells (CD4⁺CD45RO⁺CXCR5⁺). (B) Proportion of activated Tfh (CD4⁺CD45RO⁺CXCR5⁺PD1^high). (C) Proportion of a CCR7^low expressing cTfh (CD4⁺CD45RO⁺CXCR5⁺CCR7^lowPD1^high). (D) Representative scatter dot plot flow-cytometry panel highlighting the expansion of the CCR7^lowPD1^high Tfh subset in PBMC from patient with ALPS-FAS with or without CD4 lymphopenia.