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. 2019 May 29;10:1082. doi: 10.3389/fmicb.2019.01082

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Copyright © 2019 Ming, Geng, Feng, Lu, Zhou, Li, Zhang, He, Li, Cheong and Su.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relevant metabolic pathways and the accumulation of major intracellular osmoprotectants in S. aureus. Red font indicates upregulated proteins, and green font indicates downregulated proteins. Candidate proteins include oxygen-dependent choline dehydrogenase (BetA), betaine-aldehyde dehydrogenase (BetB), glutamine synthetase (GlnA), proline/betaine transporter (ProP), and glycine betaine transporter (OpuD), citrate synthase (CS), glutamate dehydrogenase (Gdh), isocitrate dehydrogenase (IDH), aconitate hydratase (ACO), oxoglutarate dehydrogenase complex (OGDC), 3-oxoacyl-[acyl-carrier-protein] synthase 2 (FabF), and malonyl CoA-acyl carrier protein transacylase (FabD).