Table 1.

Genetic modifiers that may modify multiple ALS genes. This list includes the human orthologs that were identified as modifiers of more than one ALS-causal genes (e.g. SRRT orthologs were reported as modifiers in both SOD1 and TDP43 models). Additionally, human genes reported as modifiers through GWAS or linkage analysis studies are also included in this list.

Human Gene	Organism	Modifier for	Reference
ATXN2	Yeast, Human	TDP43, Human	(Elden et al., 2010; Figley and Gitler, 2013; Lee T. et al., 2011)
BMP2	Nematode, Fly	SOD1, C9orf72	(Wang J. et al., 2009; Zhang et al., 2015)
CCNB1	Yeast, Fly	FUS, VAPB	(Sanhueza et al., 2015; Sun Z. et al., 2011)
CCT4	Nematode, Fly	SOD1, C9orf72	(Lee K. H. et al., 2016; Wang J. et al., 2009)
CDC6	Yeast, Fly	C9orf72, VAPB	(Deivasigamani et al., 2014; Jovicic et al., 2015)
CHGB	Mouse, Human	SOD1, Human	(Gros-Louis et al., 2009; Ohta et al., 2016)
COA4	Nematode, Yeast	SOD1, FUS	(Sun Z. et al., 2011; Wang J. et al., 2009)
DAZAP1	Fly	C9orf72, VCP	(Ritson et al., 2010; Zhang et al., 2015)
DBR1	Yeast	TDP43, FUS	(Armakola et al., 2012; Figley and Gitler, 2013)
DNAJA1	Yeast, Fly	SOD1, C9orf72	(Lee K. H. et al., 2016; Strain et al., 1998)
FBXW7	Nematode, Yeast	SOD1, FUS	(Sun Z. et al., 2011; Wang J. et al., 2009)
GNAQ	Fly	C9orf72, VAPB	(Deivasigamani et al., 2014; Zhang et al., 2015)
HNRNPC	Yeast, Fly	C9orf72, FUS	(Lee K. H. et al., 2016; Sun Z. et al., 2011)
IMPA1	Yeast, Fly	FUS, VAPB	(Deivasigamani et al., 2014; Sun Z. et al., 2011)
IPO5	Fly	C9orf72, VAPB	(Deivasigamani et al., 2014; Lee K. H. et al., 2016)
KPNB1	HeLa cells, Fly	TDP43, C9orf72, VAPB	(Boeynaems et al., 2016; Kim S. H. et al., 2012; Sanhueza et al., 2015)
MMP9	Mouse, Human	SOD1, Human	(Kaplan et al., 2014; Lorenzl et al., 2006)
MRPL33	Yeast	TDP43, FUS	(Armakola et al., 2012; Sun Z. et al., 2011)
NAA20	Fly	C9orf72, VAPB	(Deivasigamani et al., 2014; Zhang et al., 2015)
NCL	Yeast, Fly	C9orf72, FUS	(Lee K. H. et al., 2016; Sun Z. et al., 2011)
NOB1	Nematode, Yeast	SOD1, C9orf72	(Jovicic et al., 2015; Wang J. et al., 2009)
NUP50	Fly	TDP43, C9orf72	(Boeynaems et al., 2016; Freibaum et al., 2015; Zhan et al., 2013)
NUP107	Fly	FUS, C9orf72	(Boeynaems et al., 2016; Sun Z. et al., 2011)
PDE6D	Nematode, Fly	SOD1, VAPB	(Deivasigamani et al., 2014; Silva et al., 2011)
PELO	Yeast, Fly	TDP43, C9orf72	(Armakola et al., 2012; Jovicic et al., 2015)
PGM1	Yeast, Fly	TDP43, C9orf72	(Kim H. J. et al., 2014; Zhang et al., 2015)
PIAS1	Nematode, Fly	SOD1, VAPB	(Sanhueza et al., 2015; Wang J. et al., 2009)
POLD3	Yeast, Fly	C9orf72, VAPB	(Deivasigamani et al., 2014; Jovicic et al., 2015)
PPP1R3C	Fly, Yeast	C9orf72, FUS	(Sun Z. et al., 2011; Zhang et al., 2015)
RAN	Human cells, Fly	TDP43, C9orf72	(Freibaum et al., 2015; Kim S. H. et al., 2012)
RBM10	Fly	C9orf72, VAPB	(Lee K. H. et al., 2016; Sanhueza et al., 2015)
SAMD4A	Yeast	TDP43, C9orf72	(Jovicic et al., 2015; Kim H. J. et al., 2014)
SCARB1	Fly	C9orf72, VAPB	(Sanhueza et al., 2015; Zhang et al., 2015)
SIRT1	Fly	C9orf72, VAPB	(Sanhueza et al., 2015; Zhang et al., 2015)
SLC17A5	Nematode, Fly	SOD1, C9orf72	(Wang J. et al., 2009; Zhang et al., 2015)
SOD1	Fly	SOD1, VAPB	(Deivasigamani et al., 2014; Kumimoto et al., 2013)
SRRT	Fly	C9orf72, VAPB	(Deivasigamani et al., 2014; Freibaum et al., 2015)
TARDBP	Fly	TDP43, C9orf72, VAPB, VCP	(Deivasigamani et al., 2014; Lee K. H. et al., 2016; Ritson et al., 2010; Sreedharan et al., 2015; Wang J. W. et al., 2011)
TNPO1	Fly	C9orf72, VAPB	(Boeynaems et al., 2016; Deivasigamani et al., 2014)
TOP1	Nematode, Fly	SOD1, C9orf72	(Lee K. H. et al., 2016; Wang J. et al., 2009)
UBR5	Yeast, Fly	TDP43, C9orf72	(Kim H. J. et al., 2014; Lee K. H. et al., 2016)
UQCRC2	Nematode, Fly	SOD1, VAPB	(Deivasigamani et al., 2014; Silva et al., 2011)
XPO1	Nematode, Fly	SOD1, C9orf72	(Silva et al., 2011; Zhang et al., 2015)