FIGURE 2.

Gene-specific histone H3K4 trimethylation in the livers of STAM mice during hepatocarcinogenesis. (A) The changes in the level of histone H3 lysine 4 trimethylation in the promoter region of selected genes at NAFL (6 weeks), NASH-fibrotic (12 weeks), and full-fledged HCC (20 weeks) stages of NASH-associated liver carcinogenesis. Dashed line indicates threshold level, which was selected as a twofold change comparing to control age-matched mice (Log₂ fold change = +1 and −1). (B) Pearson correlation P-value between gene expression and change in the promoter region histone H3 lysine 4 trimethylation in the livers of mice subjected to STAM hepatocarcinogenesis at 6, 12, and 20 weeks. Dashed line indicates the threshold level, which was selected as P = 0.05 (Log₂ P = −4.13).