Figure 5.

Cell-free DNA concentration increases during neoadjuvant chemotherapy. (A) Each point represents the average cell-free DNA concentration for all plasma samples from a single patient under a single treatment condition. Each of the ten patients had at least one pretreatment sample, and one of AC or paclitaxel treatments. Five patients have had both AC and paclitaxel treatments. Error bars ± SEM. (B) Serial cell-free DNA quantification of patient TB39. Second time point (day 28) corresponded with patient toxicity. (Ganet) Ganetenib, an HSP-90 inhibitor.