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. 2019 Apr;5(2):a003566. doi: 10.1101/mcs.a003566

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© 2019 Lund-Andersen et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial License, which permits reuse and redistribution, except for commercial purposes, provided that the original author and source are credited.

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Figure 6. — Simplified overview of the main pathways (Hippo, PI3K/AKT/mTOR, DNA repair, and chromatin remodeling) affected by the molecular alterations found by integrative genomic analysis in this case of peritoneal mesothelioma. Depicted mutations and copy-number loss (stars) were present in tumor samples before (T1) and after (T2) chemotherapy, whereas components marked up- or down-regulated (triangles) refer to the state in T2 compared to T1.