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. 2019 May 28;9(5):e024078. doi: 10.1136/bmjopen-2018-024078

Table 4.

Medication use according to sex, age and BMI weight classification

% Sex Age groups Body mass index (kg/m2)
Men Women 18–39 40–49 50–59 60+ Underweight Normal weight Over weight Obese Morbidly obese
Medication
Acid reflux 5.75 5.56 5.81 3.02 4.54 7.14 8.36 3.57 4.34 5.36 7.19 9.14
 Risk ratio 1.00 1.04 1.00 1.50 2.36 2.77 0.82 1.00 1.24 1.66 2.11
 AFp (%) 0.00 0.26 0.00 2.81 7.27 9.23 0.00 1.33 3.64 5.98
Acne 7.17 3.15 8.62 7.15 7.03 7.16 7.40 9.82 8.81 6.64 6.34 6.18
 Risk ratio 1.00 2.74 1.00 0.98 1.00 1.03 1.11 1.00 0.75 0.72 0.70
 AFp (%) 0.00 11.07 0.00 0.01 0.25 0.82 0.00
Antibiotic 21.21 17.81 22.44 18.72 20.76 22.76 21.93 25.89 20.54 20.74 23.73 21.24
 Risk ratio 1.00 1.26 1.00 1.11 1.22 1.17 1.26 1.00 1.01 1.16 1.03
 AFp (%) 0.00 5.23 0.00 2.26 4.38 3.51 5.24 0.00 0.21 3.19 0.72
Anticonvulsants 1.49 1.39 1.53 1.84 1.32 1.45 1.40 2.68 1.25 1.13 1.65 1.61
 Risk ratio 1.00 1.10 1.00 0.72 0.79 0.76 2.14 1.00 0.90 1.32 1.29
 AFp (%) 0.00 0.15 0.00 1.68 0.00 0.47 0.43
Antifungal 5.29 2.61 5.81 5.64 6.03 4.24 3.87 5.36 5.83 3.81 6.24 6.18
 Risk ratio 1.00 2.23 1.00 1.07 0.75 0.69 0.92 1.00 0.65 1.07 1.06
 AFp (%) 0.00 6.09 0.00 0.36 0.00 0.37 0.32
Anxiety 7.88 6.31 8.45 6.42 7.80 8.36 8.97 8.93 7.22 7.11 7.29 6.45
 Risk ratio 1.00 1.34 1.00 1.21 1.30 1.40 1.24 1.00 0.98 1.01 0.89
 AFp (%) 0.00 2.60 0.00 1.67 2.33 3.03 1.83 0.00 0.08
Arthritis 11.06 11.13 11.03 7.72 10.53 12.83 12.56 7.14 9.36 10.72 13.84 14.78
 Risk ratio 1.00 0.99 1.00 1.36 1.66 1.63 0.76 1.00 1.15 1.48 1.58
 AFp (%) 0.00 0.00 3.87 6.82 6.48 0.00 1.58 5.03 6.02
Asthma 8.61 7.19 9.13 7.48 8.80 8.00 11.22 6.25 6.24 8.74 10.39 10.75
 Risk ratio 1.00 1.27 1.00 1.18 1.07 1.50 1.00 1.00 1.40 1.67 1.72
 AFp (%) 0.00 2.27 0.00 1.50 0.59 4.13 0.01 0.00 3.33 5.42 5.86
Birth control 8.71 0.24 10.88 21.13 8.77 2.59 0.95 10.71 11.69 7.30 6.34 6.99
 Risk ratio 1.00 45.33 1.00 0.42 0.12 0.04 0.92 1.00 0.62 0.54 0.60
 AFp (%) 0.00 79.43 0.00 0.00
Blood thinner 1.26 1.85 1.05 3.91 18.75 45.31 32.03 0.95 0.52 1.15 2.08 5.22
 Risk ratio 1.00 0.57 1.00 4.80 11.59 8.19 1.83 1.00 2.21 4.00 10.04
 AFp (%) 0.00 0 4.56 11.77 8.31 1.03 0 1.50 3.64 10.22
Bowel/rectum 3.06 2.75 3.17 1.76 2.84 3.53 4.15 1.79 3.15 2.87 2.85 2.96
 Risk ratio 1.00 1.15 1.00 1.61 2.01 2.36 0.57 1.00 0.91 0.90 0.94
 AFp (%) 0.00 0.47 0.00 1.84 2.99 3.99 0.00
Cold/influenza/allergy 17.80 14.52 18.99 15.73 18.30 18.14 19.07 22.32 15.53 18.56 20.38 22.04
 Risk ratio 1.00 1.31 1.00 1.16 1.15 1.21 1.44 1.00 1.20 1.31 1.42
 AFp (%) 0.00 5.20 0.00 2.83 2.65 3.64 7.22 0.00 3.36 5.27 6.94
Depression 18.24 10.28 21.14 12.51 19.30 20.75 18.84 15.18 16.20 17.59 20.83 18.55
 Risk ratio 1.00 2.06 1.00 1.54 1.66 1.51 0.94 1.00 1.09 1.29 1.15
 AFp (%) 0.00 16.16 0.00 9.01 10.73 8.45 0.00 1.54 4.95 2.58
Diabetes 6.32 6.48 6.22 2.53 4.50 7.82 10.94 1.79 2.24 5.67 11.29 17.74
 Risk ratio 1.00 0.96 1.00 1.78 3.09 4.32 0.80 1.00 2.53 5.04 7.92
 AFp (%) 0.00 0.00 4.69 11.67 17.36 0.00 8.82 20.34 30.43
Oedema 5.14 3.12 5.87 2.04 3.64 6.48 8.86 6.25 3.08 4.66 7.29 12.90
 Risk ratio 1.00 1.88 1.00 1.78 3.18 4.34 2.03 1.00 1.51 2.37 4.19
 AFp (%) 0.00 4.33 0.00 3.88 10.06 14.66 5.02 0.00 2.57 6.56 14.08
Eye infection 12.01 9.23 12.87 11.44 13.06 11.13 12.34 14.29 11.02 12.12 13.64 9.68
 Risk ratio 1.00 1.39 1.00 1.14 0.97 1.08 1.30 1.00 1.10 1.24 0.88
 AFp (%) 0.00 4.52 0.00 1.67 0.94 3.44 0.00 1.18 2.78
Herpes 6.30 3.26 6.86 4.82 7.24 6.12 4.71 1.79 7.66 7.22 4.20 1.88
 Risk ratio 1.00 2.10 1.00 1.50 1.27 0.98 0.23 1.00 0.94 0.55 0.25
 AFp (%) 0.00 6.50 0.00 3.07 1.67 0.00
High blood pressure 16.49 19.95 15.60 4.58 11.05 22.78 29.39 6.25 8.54 17.44 24.68 31.99
 Risk ratio 1.00 0.78 1.00 2.41 4.97 6.42 0.73 1.00 2.04 2.89 3.75
 AFp (%) 0.00 0.00 18.89 39.59 47.18 0.00 14.66 23.76 31.17
Inflammation 1.19 0.68 1.37 0.69 0.87 1.50 1.68 1.79 0.98 1.40 0.80 1.61
 Risk ratio 1.00 2.01 1.00 1.26 2.17 2.43 1.83 1.00 1.43 0.82 1.64
 AFp (%) 0.00 1.19 0.00 0.31 1.38 1.68 0.97 0.00 0.51 0.76
Insomnia 4.23 2.24 4.95 2.70 3.60 5.72 4.04 8.93 4.07 3.92 3.85 4.84
 Risk ratio 1.00 2.21 1.00 1.33 2.12 1.50 2.19 1.00 0.96 0.95 1.19
 AFp (%) 0.00 4.87 0.00 1.39 4.52 2.06 4.81 0.00 0.79
Muscle spasms 4.34 3.53 4.64 3.11 4.57 4.93 4.37 5.36 3.29 4.27 5.44 6.99
 Risk ratio 1.00 1.31 1.00 1.47 1.59 1.41 1.63 1.00 1.30 1.65 2.12
 AFp (%) 0.00 1.35 0.00 2.00 2.48 1.73 2.66 0.00 1.28 2.76 4.65
Nausea/vomiting 5.01 3.77 5.47 5.44 4.85 4.83 5.10 4.46 4.14 4.50 6.19 5.65
 Risk ratio 1.00 1.45 1.00 0.89 0.89 0.94 1.08 1.00 1.09 1.50 1.36
 AFp (%) 0.00 2.21 0.00 0.39 0.00 0.43 2.42 1.79
Opioids 17.04 15.98 17.42 14.14 16.29 18.62 18.73 17.86 13.39 15.77 20.28 27.69
 Risk ratio 1.00 1.09 1.00 1.15 1.32 1.32 1.33 1.00 1.18 1.51 2.07
 AFp (%) 0.00 1.51 0.00 2.53 5.12 5.24 5.38 0.00 2.94 8.06 15.40
Osteoporosis 1.21 0.07 1.63 0.00 0.17 1.30 4.37 0.89 1.56 1.20 0.85 0.00
 Risk ratio 1.00 23.29 1.00 0.57 1.00 0.77 0.54 0.00
 AFp (%) 0.00 21.24 0.00 0.00
Pain–non-opioid 2.19 1.63 2.39 2.78 2.15 1.98 1.91 3.57 1.73 1.67 2.55 2.96
 Risk ratio 1.00 1.47 1.00 0.77 0.71 0.69 2.06 1.00 0.97 1.47 1.71
 AFp (%) 0.00 1.01 0.00 2.28 0.00 1.03 1.53
Skin 6.84 4.88 7.55 5.44 6.44 7.37 8.24 6.25 7.25 6.41 7.19 5.38
 Risk ratio 1.00 1.55 1.00 1.18 1.35 1.51 0.86 1.00 0.88 0.99 0.74
 AFp (%) 0.00 3.61 0.00 1.24 2.37 3.40 0.00
Statins 14.49 17.93 13.24 2.31 8.53 20.58 28.4 3.81 7.02 17.95 19.89 27.47
 Risk ratio 1.00 0.74 1.00 3.69 8.91 12.29 0.54 1.00 2.56 2.83 3.91
 AFp (%) 0.00 0.00 28.07 53.40 62.07 0.00 18.41 20.99 29.68
Stomach acid 1.19 1.49 1.07 0.86 1.25 0.99 1.96 0.89 0.81 1.01 1.90 1.08
 Risk ratio 1.00 0.72 1.00 1.45 1.15 2.28 1.10 1.00 1.25 2.35 1.33
 AFp (%) 0.00 0.00 0.54 0.18 1.50 0.12 0.00 0.29 1.58 0.40
Teeth/gums 0.43 0.37 0.46 0.37 0.35 0.43 0.67 0.00 0.27 0.43 0.35 0.27
 Risk ratio 1.00 1.24 1.00 0.95 1.16 1.81 0.00 1.00 1.59 1.30 1.00
 AFp (%) 0.00 0.10 0.00 0.07 0.35 0.00 0.25 0.13 0.00
Thyroid 12.76 2.99 16.31 4.37 11.19 16.92 17.61 6.25 13.97 12.74 13.94 19.09
 Risk ratio 1.00 5.45 1.00 2.56 3.87 4.03 0.45 1.00 0.91 1.00 1.37
 AFp (%) 0.00 36.24 0.00 16.61 26.82 27.88 0.00 4.47
Ulcers 9.38 8.55 9.69 8.30 8.28 10.19 10.88 10.71 7.59 9.90 10.99 15.32
 Risk ratio 1.00 1.13 1.00 1.00 1.23 1.31 1.41 1.00 1.30 1.45 2.02
 AFp (%) 0.00 1.24 0.00 2.09 2.83 3.71 0.00 2.78 4.03 8.72
Urinary tract infection 3.01 0.20 4.44 3.39 3.08 3.45 3.25 6.25 3.83 2.83 3.50 3.76
 Risk ratio 1.00 22.20 1.00 0.91 1.02 0.96 1.63 1.00 0.74 0.91 0.98
 AFp (%) 0.00 38.95 0.00 0.05 1.87 0.00
Vitamins/minerals 2.07 0.71 2.57 2.49 1.73 1.88 2.47 0.00 2.07 1.28 1.75 5.38
 Risk ratio 1.00 3.62 1.00 0.69 0.76 0.99 0.00 1.00 0.62 0.85 2.60
 AFp (%) 0.00 5.14 0.00 0.00 3.20
All prescriptions 80.87 71.40 84.32 71.52 78.45 85.24 88.00 83.93 81.46 81.28 83.47 86.29
 Risk ratio 1.00 1.18 1.00 1.10 1.19 1.23 1.03 1.00 1.00 1.02 1.06
 AFp (%) 0.00 12.77 0.00 7.27 13.43 15.71 2.39 0.00 1.96 4.58

Shaded cells represent statistical significance at the 0.05 level. Cells that are left blank had a negative AFp. In these cases, the preventive fraction ([risk ratio–1]×100) is more appropriate.

AFp, attributable fraction in the population; BMI, body mass index.