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. 2019 May 27;12:4153–4165. doi: 10.2147/OTT.S195675

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© 2019 Li et al.

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Bioinformatic analysis of DEGs including GO, KEGG and PPI network. (A and B) Bubble plot for GO enrichment of DEGs in GSE12102 and GSE17618 dataset based on GO analysis. X-axis represents the gene ratio and y-axis descript the enrichment components. The area of the circle is proportional to the number of genes assigned to the term and the color accords with the P-value. (C and D) separately showed the KEGG pathways in GSE12102 and GSE17618 dataset. (E) showed the potential intermolecular interactions of the key genes. The different color lines reflect interaction relationship, respectively. (F) Overview of MMR pathway. Pink represents the differently expressed genes (P<0.01); blue represents undifferentiated expressed genes (P>0.01).

Abbreviations: DEGs, differentially expressed genes; GO, gene ontology; KEGG, Kyoto encyclopedia of genes and genomes; PPI, protein–protein interaction; MMR, mismatch repair.