Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 17;12(5):dmm038109. doi: 10.1242/dmm.038109

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

PMC Copyright notice

Fig. 2. — The effect of TDP-43^A315T expression on dendrite development. (A) Primary cortical neurons derived from YFP:WT (left) and YFP:TDP-43^A315T (right) single embryo cultures labeled for MAP2 at 3 DIV, 5 DIV, 10 DIV and 15 DIV. (B) Total dendrite length significantly increased between 3 and 15 DIV in both WT and TDP-43^A315T cultures. There was no significant difference in total dendrite length between WT and TDP-43^A315T at any time point. (C) Mean dendrite length significantly increased between 3 and 15 DIV in both WT and TDP-43^A315T cultures. There was no significant difference in mean dendrite length between WT and TDP-43^A315T at any time point. (D) There was no significant difference in dendritic branching number between 3 and 15 DIV in both WT and TDP-43^A315T cultures. There was no significant difference in dendritic branching number between WT and TDP-43^A315T neurons at any time point. (E) Quantification of the number of primary (1°) secondary (2°) tertiary (3°) and quaternary (4°) dendrite branches at 3, 5, 10 and 15 DIV demonstrated that TDP-43^A315T neurons became significantly less complex in quaternary branches by 15 DIV. n=3 biological replicates. *P<0.05 (two-way ANOVA with Tukey's multiple comparisons test). Data are mean±s.e.m. Scale bars: 20 μm.