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. 2019 May 30;12(5):dmm037887. doi: 10.1242/dmm.037887

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — Regulation of immune-related genes in macrophages, determined by RNA-seq analysis. For all genes significantly regulated upon amputation, the fold change due to amputation (Amp; red bars), beclomethasone (Beclo; green bars) and the combined amputation/beclomethasone treatment (Amp+Beclo; blue bars) is shown. The results show that beclomethasone dampens the amputation-induced expression of most genes, but for three genes (cd22, alox5ap, tlr5b) the combined treatment results in a higher fold change compared to the amputation treatment. Paired analysis was performed using DESeq (v1.26.0) R package by comparing each group to the control group (non-amputated/vehicle treated). Significantly regulated genes were selected by using a p.adj<0.05 and |FoldChange|>2 cutoff.