Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 30;12(5):dmm038513. doi: 10.1242/dmm.038513

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

PMC Copyright notice

Fig. 4. — Increased osteoclastogenesis in the mandibular bone of Fgfr2^+/S252W embryos at E16.5. (A-H) The differential expression of Csf1r and Itgb3 in the mandible of Fgfr2^+/+ (A,B,E,F) and Fgfr2^+/S252W (C,D,G,H) embryos were validated by in situ hybridization (ISH). B,D,F and H show higher magnification of the boxed areas in A,C,E and G, respectively. (I-J) TRAP assay stained osteoclasts (purple) in the mandible of Fgfr2^+/+ (I) and Fgfr2^+/S252W (J) embryos. (K-L) Quantitative measurements of the density (K) and percentage (L) of osteoclasts in the bone area of Fgfr2^+/+ (n=3) and Fgfr2^+/S252W (n=3) embryos. Data are mean±s.e.m. *P<0.05, two-tailed Welch's t-test. Scale bars: 100 µm.