Fig. 2.

Focal adhesion pathway (A) and HIF-1 signaling pathway (B) altered in a CRC. Green rectangles with a red mark indicate the identified proteins. Green rectangles without a red mark indicate species-specific enzymes. White rectangles indicate reference pathway. The solid line indicates molecular interaction. The dashed line indicates indirect effect. The pathway node in the right panel corresponds to the red marked node in the left diagram. ID number is the Swiss-Prot accession number. Ratio (T/N)=Ratio of TVECs to controls.