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. 2019 Apr 29;8(5):bio042838. doi: 10.1242/bio.042838

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Reduction of tumor-derived TNC inactivate ITGB3/FAK/Akt signaling in HUVECs. (A,B) TNC protein levels in total cell and conditioned medium from untransfected (SW620), empty vector (SW620/Vector) and TNC-shRNA plasmid transfected SW620 cells (SW620/shTNC) were detected by western blot analysis. (C) Treatment with conditioned media (CM) from SW620/sh-TNC cells decreased ITGB3, phosphorylation of FAK-397 and phosphorylation of Akt-473 in HUVECs as compared with CM from untransfected SW620 cells.