Fig. 4.
Effect of SB 216,641 (0.8 mg/kg), 5-HT1B antagonist, on antinociceptive effect of paracetamol (125 and 250 mg/kg; A and B respectively). SB 216,641 was administered 15 min after paracetamol administration. Formalin test was performed 30 min after of paracetamol administration. Two phases of spontaneous flinches/shakes behavior were observed over the 60 min test period. Error bars represent the SEM of 10–11 animals/group. * p < 0.05 vs saline and SB as assessed by one-way ANOVA followed by a Newman-Keuls post-test.