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. 2018 Jul 20;5:100021. doi: 10.1016/j.ynpai.2018.07.002

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© 2018 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Supplementary Fig. S2 — Average density of neural profiles (bars and SEM) characterized as peptidergic and nonpeptidergic for each ipsilateral FC18, PC10, PC28, PNT28, and Sham28 biopsy (see Table 1, Part 1). PC10 bars are unfilled since they involve a purposefully shorter post-operative time. (A) IENF density. Red bars are the average peptidergic fiber density defined as profiles within the epidermis that co-label for CGRP and PGP. Blue bars are the average nonpeptidergic fiber density as profiles that only label for PGP. Purple bars are the average density of both types that have a discernible entry into the epidermis defined as a contact with or passage through the epidermal basement membrane. (B–D) Subepidermal (B), upper dermal non-vascular (C), and upper dermal vascular (D). Red bars are the average peptidergic fiber density defined as profiles that only co-label for CGRP and PGP. Blue bars are the average nonpeptidergic fiber density as profiles that only label for PGP. Purple bars are those profiles that can contain at least one peptidergic and one nonpeptidergic axon.

Supplementary Fig. S2 — Average density of neural profiles (bars and SEM) characterized as peptidergic and nonpeptidergic for each ipsilateral FC18, PC10, PC28, PNT28, and Sham28 biopsy (see Table 1, Part 1). PC10 bars are unfilled since they involve a purposefully shorter post-operative time. (A) IENF density. Red bars are the average peptidergic fiber density defined as profiles within the epidermis that co-label for CGRP and PGP. Blue bars are the average nonpeptidergic fiber density as profiles that only label for PGP. Purple bars are the average density of both types that have a discernible entry into the epidermis defined as a contact with or passage through the epidermal basement membrane. (B–D) Subepidermal (B), upper dermal non-vascular (C), and upper dermal vascular (D). Red bars are the average peptidergic fiber density defined as profiles that only co-label for CGRP and PGP. Blue bars are the average nonpeptidergic fiber density as profiles that only label for PGP. Purple bars are those profiles that can contain at least one peptidergic and one nonpeptidergic axon.