Fig. 2.

Changes of daily running distances in Naive, Sham and PSL-Runner mice throughout the experimental period. Naive-Runner (n = 5), Sham-Runner (n = 5) and PSL-Runner (n = 5) mice were placed in individual cages equipped with the low-profile wireless mouse running wheel, and daily running distances (m/day) were recorded throughout the experimental period. The distance traveled on the running wheel was monitored using a magnetic reed switch attached to a computerized exercise-monitoring system (SOF-860 wheel manager software, MED associates, Inc). Although in PSL-Runner mice, PSL surgery dramatically reduced the running distance at 1 day post-surgery, these levels gradually returned to nearly pre-surgical level at 15 days after PSL surgery. Adapted with permission from Kami et al. (2016c).