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Simplified schematic drawing of the major neural circuit connections involved in EIH. The network displays the complex interplay in regulating cellular activity within the reward system and several nuclei projecting to the VTA. GABA: gamma-aminobutyric acid, LDT: laterodorsal tegmental nucleus, LHb: lateral habenula, mPFC: medial prefrontal cortex, NAc: nucleus accumbens, PPTg: pedunculopontine tegmental nucleus, RMTg: rostromedial tegmental nucleus, VTA: ventral tegmental area.
