Table 2.
Herpes simplex virus (HSV) hepatitis complicated by hemophagocytic lymphohistiocytosis (HLH) reported in the literature
| Source | HSV serotype | HLH criteria6 met | Ferritin (ng/dL) | Bone marrow obtained? | Treatment | Outcome |
|---|---|---|---|---|---|---|
| Fenaux et al,7 1986 | 1 | Fever Splenomegaly Pancytopenia Hypertriglyceridemia/hypofibrinogenemia Hemophagocytosis in bone marrow |
NA | Yes | Acyclovir, IVIG, vinblastine | Died |
| Mihalcea-Danciu et al,8 2014 | 1+2 | Fever Bicytopenia Hypertriglyceridemia Hyperferritinemia |
201,000 | No | Acyclovir | Survived |
| Lasserre et al,9 1993 | 2 | Fever Bicytopenia Hemophagocytosis in bone marrow |
NA | Yes | Acyclovir, IVIG | Survived |
| Alidjinou et al,10 2015 | 1 | Fever Bicytopenia Hypertriglyceridemia/hypofibrinogenemia Hyperferritinemia Hemophagocytosis in bone marrow |
62,427 | Yes | Acyclovir, etoposide | Survived |
| Honsig et al,11 2017 | 1 | Fever Splenomegaly Pancytopenia Hyperferritinemia Increased soluble IL-2 receptor Hemophagocytosis on liver biopsy |
7058 | No | Acyclovir | Died |
IL = interleukin; IVIG = intravenous immunoglobulin; NA = not available.