Fig. 7.

Generalized Wnt signaling networks. In the absence of activating Wnt ligands (top panel, -Wnt), beta-catenin protein (Ctnnb1) is phosphorylated by destruction complex components and tagged for proteasomal degradation. In the nucleus, Tcf7l1/Tcf3 represses Wnt target promoter activity through recruitment of Groucho. Upon stimulation with Wnt ligand, a variety of pathways are activated (see text for details). Predominantly positive-acting components with respect to beta-catenin regulation are shown in green, negative components in red, beta-catenin-independent components are light blue. Beta-catenin is shown in yellow. Circles indicate component nodes, lines indicate edges, or interacting components. This arrangement is not meant to convey specific exact binding relationships or stoichiometry. Wnt1 is shown as a beta-catenin-activating ligand, whereas Wnt5 is shown as a Wnt/PCP and Wnt/Calcium-stimulating ligand. Plot was generated with iGraph in R (Csardi and Nepusz 2014). txn transcription