Table 2.
Genomic regions identified by genome-wide association analysis or candidate gene analysis as associated with sire conception rate.
| SNP | Location (Chr:bp) | Gene(s)1 |
|---|---|---|
| rs1361956182 | 7:41 208 950 | PROP1 |
| SNP116464,5 | 17:35 247 641–35 247 4906 | FGF2 |
| SNP121954,5 | 19:43 045 658–43 046 4776 | STAT5A |
| 1.5 Mb window7 | 5:105 357 507–106 813 133 | PARP11, AKAP3 |
| rs425593737,8 | 9:11 867 269 | RIMS1 |
| 1.5 Mb window7 | 13:58 456 868–59 951 247 | CTCFL, SPO11 |
| rs422961087 | 15:26 472 899 | CADM1 |
| 1.5 Mb window7 | 21:8 031 396–9 528 223 | IGF1R |
| 1.5 Mb window7 | 21:68 846 429–70 294 301 | TDRD9, CKB |
| rs1106973187 | 21:71 210 609 | BRF1 |
| 1.5 Mb window7,8 | 25:3 148 958–4 647 188 | MGRN1, SEPT12 |
| 1.5 Mb window7 | 25:26 736 589–28 233 820 | CCT6A |
| rs415675167 | 25:27 477 941 | KAT8 |
| rs4206518327,9 | 25:27 672 891 | ITGAM |
| rs416496817 | 25:28 711 626 | TYW1 |
| rs4164228310 | 2:24 837 034 | DYNC1I2 |
| rs10905943810 | 5:112 775 479 | LOC784935 |
| rs4157187810 | 18:54 965 977 | ZNF541 |
| rs1106296618,10 | 25:983 759 | CACNA1H |
| rs1097582488,10 | 25:2 270 518 | LOC617302 |
| rs1101298888,10 | 25:3 898 682 | ROGDI |
| rs1103832248,10 | 25:4 229 011 | LOC521021 |
| rs4248022310 | 29:14 271 174 | - |
| rs412571811,12 | 1:69 802 307 | ITGB5 |
| rs290248611,12 | 4:11 622 140 | COL1A2-AS1 |
| rs290155748,12 | 9:12 042 726 | RIMS1 |
| rs2901687512 | 10:6 003 240 | SFNX1, DRD1 |
1
SNP located within or near identified gene or window contains the listed genes.
3
Sire conception rate.
4
Estimated relative conception rate.
6
PCR amplicon contains identified SNP but exact reference genome position not provided.
8
QTL validated in two or more studies.
9
rs number corresponds to marker name but provided chromosomal coordinates are not correct.
11
Validated in follow-up analysis of expanded genotyped sample.