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Kinetic parameters for in vitro biotransformation of phenanthrene, pyrene, and benzo[a]pyrene by trout liver S9 fractions
| Phenanthrene | Pyrene | Benzo[a]pyrene | |
|---|---|---|---|
| Log Kowa | 4.47 | 4.88 | 6.13 |
| KM (μM) | 0.52 | 0.070 | 0.030 |
| Vmax (pmol/min/mg protein) | 22.5 | 40.9 | 28.7 |
| CLin vitro,int (mL/h/mg protein) | 2.6 | 35.1 | 57.4 |
Based on MLogP estimates (with preference given to measured values) in Bio-Loom for Windows.57
