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. 2019 Jun 5;17(6):e2005326. doi: 10.1371/journal.pbio.2005326

Fig 7. Ngl3−/−(Hyb) and Ngl3−/−(B6) mice display anxiolytic-like behavior.

Fig 7

(A) Anxiolytic-like behavior of Ngl3−/−(Hyb) mice (2–4 months) in the elevated plus maze test, as shown by time spent in open/closed arms. Note that Ngl3−/−(Hyb) mice are also hyperactive in this test. n = 22 mice for WT and 25 for KO, ***P < 0.001, Student t test. (B) Normal anxiety-related behavior of Ngl3−/−(Hyb) mice (2–4 months) in the light-dark test, as shown by transition number and chamber time. n = 22 mice for WT and 25 for KO; ns, not significant, Student t test. (C) Anxiolytic-like behavior of Ngl3−/−(B6) mice (2–4 months) in the elevated plus maze test, as shown by time spent in open/closed arms. n = 17 mice for WT and 10 for KO; ***P < 0.001, ns, not significant, Student t test. (D) Anxiolytic-like behavior of Ngl3−/−(B6) mice (2–4 months) in the light-dark test, as shown by time in the light chamber and transition number. n = 20 mice for WT and 11 for KO; **P < 0.01, ***P < 0.001, Student t test. Primary data can be found in S3 Data. KO, knockout; KO-B, knockout, C57BL/6; KO-H, knockout, hybrid; ns, not significant; WT, wild-type.