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. 2019 Jun 5;14(6):e0217819. doi: 10.1371/journal.pone.0217819

Fig 2. Loss of Dgki enhances histamine-induced scratching in male and female mice.

Fig 2

An acute scratching assay was used to test itch responses in Dgki-/- mice following an injection of 500 μg histamine (A-B), 200 μg chloroquine (C-D), or 500 μg β-alanine (E-F) in WT and Dgki-/- male (A,C,E) and female (B,D,F) mice in 5 minute intervals. The number of mice of each sex tested for all pruritogens is indicated in parentheses in (A) and (B). Graphs show mean ± SEM. p< *0.05, **0.01, ***0.001, ****0.0001.