Table 2. Adverse events (AEs) following treatment with a single dose of IVM, DEC, and ALB.
| Number of participants with AEs (percent) | ||
|---|---|---|
| Infected | Uninfected | |
| (n = 32) | (n = 24) | |
| At least one AE | 32 (100) | 24 (100) |
| Individuals with two or more AEs | 30 (94) | 20 (88) |
| Severe or Serious AEs | 0 | 0 |
| Fever ≥ 37.5°C§ | 16 (50) | 4 (17) |
| Hemodynamic changes¶ | 7 (22) | 6 (25) |
| Hematuria | 10 (31) | 3 (13) |
| Overall Grade 1 AEs (subjective) | 32 (100) | 23 (96) |
| Overall Grade 2 AEs (subjective) | 9 (28) | 6 (25) |
| Subjective AEs by symptoms | ||
| Headache | 15 (47) | 11 (46) |
| Abdominal Pain | 14 (44) | 11 (46) |
| Diarrhea | 14 (44) | 7 (29) |
| Fatigue | 10 (31) | 6 (25) |
| Muscle/Joint ache | 10 (31) | 4 (17) |
| Lightheaded | 3 (9) | 7 (29) |
| Scrotal pain/swelling* | 6/20 (30) | 0 |
| Itching | 4 (13) | 1 (4) |
| Cough | 2 (6) | 3 (13) |
| Swelling | 3 (9) | 1 (4) |
| Back pain | 1 (3) | 3 (13) |
| Rash | 1 (3) | 2 (8) |
| Nausea/vomiting | 0 | 1 (4) |
| Other† | 4 (13) | 0 |
§Temperature increased ≥0.9°C post-treatment relative to pre-treatment to at least 37.5°C based on auricular temperature
¶Systolic blood pressure decrease of 20mmHg and <100 or diastolic blood pressure decrease of 10mmHg and <50, P = 0.278
*P = 0.025
†one person each with eye selling, lymph node swelling, insomnia and paresthesia