Table 3. Association between the genotype distribution of the MICA A5.1 polymorphism (dominant and additive models) and pancreatic cancer risk.
| MICA Genotype | Cases | Controls | OR (95%CI) | p-value |
|---|---|---|---|---|
| MICA A5.1 Polymorphism (Dominant Model) | ||||
| Model 1a | ||||
| X/X | 25 | 119 | Reference | |
| X/A5.1 or A5.1/A5.1 | 96 | 300 | 1.91 (1.05–3.48) | 0.02 |
| Model 2b | ||||
| X/X | 25 | 119 | Reference | |
| X/A5.1 or A5.1/A5.1 | 96 | 300 | 1.48 (0.77–2.86) | 0.24 |
| MICA A5.1 Polymorphism (Additive Model) | p-trend | |||
| Model 3a | ||||
| X/X | 25 | 119 | Reference | |
| X/A5.1 | 65 | 176 | 2.02 (1.11–3.68) | |
| A5.1/A5.1 | 31 | 124 | 1.51 (0.71–3.22) | 0.06 |
| Model 4b | ||||
| X/X | 25 | 119 | Reference | |
| X/A5.1 | 65 | 176 | 1.57 (0.82–3.02) | |
| A5.1/A5.1 | 31 | 124 | 1.05 (0.45–2.46) | 0.94 |
a Adjusted for age (continuous variable), sex (males vs. females), education (no college vs. some college), smoking status (never, former or current), alcohol consumption (no consumption, 1–6 servings per week or 7+servings per week), and diabetes status (yes vs. no)
b Multivariate model a additionally adjusted for s-MICA levels