(A) The effect of codelivery of siP62 and/or pβ5 using cisplatin-encapsulated, chitosan-coated polylactic acid nanoparticles (CS-CDDP-PLNP) on P62 and β5 protein expression levels in cisplatin-resistant 2008/C13 cells. (B) The corresponding diagram shows relative expression levels of the two proteins normalized to beta actin. Figure reproduced from Babu, A, Wang, Q., Muralidharan, R., Shanker, M., Munshi, A, & Ramesh, R. (2014). Chitosan coated polylactic acid nanoparticle-mediated combinatorial delivery of cisplatin and siRNA/plasmid DNA chemosensitizes cisplatin-resistant human ovarian cancer cells. Molecular Pharmaceutics, 11(8), 2720–2733. doi:10.1021/mp500259e. Copyright © 2014, American Chemical Society.