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. 2019 Apr 16;92(16):e1899–e1911. doi: 10.1212/WNL.0000000000007313

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Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Meta-analysis of the results of the 23 sets of (functionally) related metabolites tested in 8 cohorts for their association with migraine. The analysis using the global test framework has been adjusted for a sex, age, body mass index, and lipid-lowering medication usage. Glutamate metabolism does not include results from the Netherlands Twin Registry as glutamine levels could not be determined in this cohort. Bars denote −log¹⁰ of the p value (Fisher combination of global test p values for the individual cohorts) per pathway, where only the black bars remain significant after multiple testing correction using Holm-Bonferroni. The threshold for withstanding multiple testing correction is indicated by a dotted line. IDL = intermediate-density lipoprotein; LDL = low-density lipoprotein; VLDL = very low-density lipoprotein.