Figure 2. MR estimates of the association between age at puberty and risk of MS.

^aGenetic association with age at voice breaking derived from a genome-wide association study of 54,871 men from 23andMe.¹⁶ BMI = body mass index; CI = confidence interval; IVW = inverse-variance weighted; MR = mendelian randomization; MS = multiple sclerosis; SNP = single-nucleotide polymorphism.