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Schematic illustrating mechanical mechanism of FSS induced cell migration and invasion in HepG2 cells. FSS induced the expressions of RhoGTPases including Rac1, RhoA and Cdc42 and the cytoskeleton remodeling via integrin/FAK pathway, leading to upregulation of Atg5 and LC3B II/I to activate autophagy. Autophagy plays important role in FSS-induced cell migration and invasion in HepG2 cells.
