Comparison 3. Antihypertensive drug therapy vs control in adults 60 years or older with isolated systolic hypertension.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Total mortality	3		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 60 to 79 years old	3	8806	Risk Ratio (M‐H, Fixed, 95% CI)	0.77 [0.65, 0.92]
1.2 80 years or older	3	1176	Risk Ratio (M‐H, Fixed, 95% CI)	1.10 [0.88, 1.38]
2 Cardiovascular morbidity and mortality	3		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 60 to 79 years old	3	8806	Risk Ratio (M‐H, Fixed, 95% CI)	0.64 [0.56, 0.73]
2.2 80 years or older	3	1176	Risk Ratio (M‐H, Fixed, 95% CI)	0.77 [0.60, 0.99]
3 Cerebrovascular morbidity and mortality	3		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 60 to 79 years old	3	8806	Risk Ratio (M‐H, Fixed, 95% CI)	0.63 [0.50, 0.79]
3.2 80 years or older	3	1176	Risk Ratio (M‐H, Fixed, 95% CI)	0.59 [0.40, 0.86]
4 Coronary heart disease morbidity and mortality	3	9982	Risk Ratio (M‐H, Fixed, 95% CI)	0.75 [0.62, 0.91]
4.1 60 to 79 years old	3	8806	Risk Ratio (M‐H, Fixed, 95% CI)	0.72 [0.58, 0.90]
4.2 80 years or older	3	1176	Risk Ratio (M‐H, Fixed, 95% CI)	0.86 [0.56, 1.32]
5 Withdrawal due to adverse effects 60 years or older	2	5287	Risk Ratio (M‐H, Fixed, 95% CI)	1.84 [1.53, 2.19]