Table 2:

Summary of reports of radionuclide-induced Cerenkov-activated photodynamic therapy.

Reference	Source	Photosensitizer	Condition	Outcome	Cerenkov photon yield per cell (200 – 800 nm)	Estimated Cerenkov PDT effect [% tumor cells killed]	Estimated dose from radionuclide [Gy]
Kotagiri et al 2015	18F	TiO-Tf-Tc	I.V. injection 2x; HT1080 mouse tumor	Median survival increased from 15 to 50 days	1.0×105	0.25	235
	18F	TiO-Tf-Tc	I.V. injection 2x; A549 mouse tumor	~6.5-fold tumor growth inhibition at day 30 compared to control	1.0×105	0.25	235
	64Cu	TiO-Tf-Tc	Direct tumor injection; HT1080 mouse tumor	Complete regression at 30 days	4.2×104	0.11	117
Kamkaew et al 2016 ‡	89Zr	HMSN-Ce6	Direct injection; 4T1 mouse tumor	Tumor growth completely inhibited within 14 days post-injection	8.6×105	2.13	973
Hartl et al 2016 †	90Y	TPPS2a	In vitro; C6 cells	Cell viability decreased ~22% compared to radiation effect alone	1.4×107	29.6	592
Nakamura et al 2017	18F	pan-IR700 (panitumumab conjugated to IR700 dye)	In vitro; A431-luc cells	Decreased A431-luc bioluminescence in dose-dependent manner (in vitro); no significant long-term therapeutic effect (in vivo)	4.13×102	0	4

^‡Expected photon yield, PDT effect, and radiation dose computed using 14 day experiment duration

^†Expected photon yield, PDT effect, and radiation dose computed using 72 hour reported incubation period