Table 2.
Association of energy-adjusted dietary vitamin B6 intake with cause-specific mortality in SMHS (2002–2014)
| Quintiles of dietary vitamin B6 intake |
|||||||
|---|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | Q5 | P for trend | Per Q | |
| Median intake (mg/d) | 1.31 | 1.53 | 1.69 | 1.87 | 2.2 | ||
| Person years | 118973 | 119988 | 120600 | 121289 | 123925 | ||
| Total mortality | |||||||
| No. of deaths | 1423 | 1227 | 1084 | 1038 | 933 | ||
| Crude HR (95%CIs) a | 1.00 (reference) | 0.79 (0.73,0.85) | 0.72 (0.67,0.78) | 0.71 (0.65,0.77) | 0.68 (0.62,0.74) | <0.001 | 0.91 (0.89,0.93) |
| Multivariable HR (95%CIs) b | 1.00 (reference) | 0.84 (0.78,0.91) | 0.82 (0.75,0.89) | 0.83 (0.76,0.90) | 0.83 (0.76,0.90) | <0.001 | 0.96 (0.94,0.98) |
| Cancer mortality | |||||||
| No. of deaths | 596 | 479 | 471 | 430 | 435 | ||
| Crude HR (95%CIs) a | 1.00 (reference) | 0.76 (0.67,0.86) | 0.77 (0.68,0.87) | 0.71 (0.63,0.81) | 0.75 (0.66,0.85) | <0.001 | 0.93 (0.91,0.96) |
| Multivariable HR (95%CIs) b | 1.00 (reference) | 0.81 (0.72,0.91) | 0.86 (0.76,0.97) | 0.82 (0.73,0.94) | 0.89 (0.78,1.01) | 0.087 | 0.97 (0.95,1.00) |
| CVD mortality | |||||||
| No. of deaths | 502 | 449 | 342 | 326 | 287 | ||
| Crude HR (95%CIs) a | 1.00 (reference) | 0.81 (0.71,0.92) | 0.64 (0.56,0.74) | 0.63 (0.55,0.73) | 0.60 (0.52,0.70) | <0.001 | 0.87 (0.85,0.90) |
| Multivariable HR (95%CIs) b | 1.00 (reference) | 0.86 (0.76,0.98) | 0.74 (0.64,0.85) | 0.75 (0.65,0.87) | 0.73 (0.63,0.85) | <0.001 | 0.92 (0.89,0.95) |
| Stroke mortality | |||||||
| No. of deaths | 268 | 226 | 167 | 154 | 140 | ||
| Crude HR (95%CIs) a | 1.00 (reference) | 0.76 (0.63,0.90) | 0.58 (0.48,0.71) | 0.55 (0.45,0.67) | 0.54 (0.44,0.67) | <0.001 | 0.85 (0.81,0.89) |
| Multivariable HR (95%CIs) b | 1.00 (reference) | 0.82 (0.69,0.99) | 0.69 (0.57,0.84) | 0.70 (0.57,0.86) | 0.71 (0.58,0.88) | <0.001 | 0.91 (0.87,0.96) |
| CHD mortality | |||||||
| No. of deaths | 110 | 105 | 71 | 78 | 58 | ||
| Crude HR (95%CIs) a | 1.00 (reference) | 0.88 (0.67,1.16) | 0.62 (0.46,0.84) | 0.71 (0.53,0.95) | 0.57 (0.42,0.79) | <0.001 | 0.87 (0.81,0.94) |
| Multivariable HR (95%CIs) b | 1.00 (reference) | 0.93 (0.71,1.22) | 0.71 (0.52,0.96) | 0.81 (0.60,1.09) | 0.66 (0.47,0.91) | 0.006 | 0.90 (0.84,0.97) |
| AMI mortality | |||||||
| No. of deaths | 74 | 85 | 50 | 66 | 47 | ||
| Crude HR (95%CIs) a | 1.00 (reference) | 1.10 (0.80,1.50) | 0.67 (0.47,0.97) | 0.91 (0.65,1.27) | 0.69 (0.48,0.99) | 0.019 | 0.91 (0.84,0.98) |
| Multivariable HR (95%CIs) b | 1.00 (reference) | 1.16 (0.84,1.59) | 0.76 (0.52,1.09) | 1.02 (0.72,1.43) | 0.78 (0.53,1.13) | 0.137 | 0.94 (0.87,1.02) |
Abbreviation: Q, quintiles; SMHS, Shanghai Men’s Health Study; HR, hazards ratio; CI, confidence interval; CVD, cardiovascular disease; CHD, coronary artery heart disease; AMI, acute myocardial infarction.
a
Crude HR: Adjusted for age at baseline, energy intake.
b
Multivariable HR: Additionally adjusted for education, income, occupation, smoke, alcohol, body mass index, waist-hip ratio, physical activity, history of diabetes, hypertension, coronary heart disease and stroke, vitamin B supplements use.