. Author manuscript; available in PMC: 2020 Jun 1.

Published in final edited form as: Clin Nutr. 2018 May 4;38(3):1180–1187. doi: 10.1016/j.clnu.2018.04.016

Table 3.

Association of energy-adjusted dietary vitamin B6 intake with cause-specific mortality in SWHS (1997–2014)

	Quintiles of dietary vitamin B6 intake
	Q1	Q2	Q3	Q4	Q5	P for trend	Per Q
Median intake (mg/d)	1.24	1.45	1.62	1.79	2.11
Person years	229890	232273	233661	234814	235497
Total mortality
No. of deaths	2169	1698	1412	1239	1037
Crude HR (95%CIs) ^a	1.00 (reference)	0.86 (0.81,0.92)	0.81 (0.76,0.87)	0.79 (0.74,0.85)	0.74 (0.68,0.79)	<0.001	0.93 (0.91,0.94)
Multivariable HR (95%CIs) ^b	1.00 (reference)	0.90 (0.85,0.96)	0.88 (0.82,0.94)	0.88 (0.81,0.94)	0.83 (0.77,0.90)	<0.001	0.96 (0.94,0.98)
Cancer mortality
No. of deaths	816	670	594	572	496
Crude HR (95%CIs) ^a	1.00 (reference)	0.91 (0.82,1.01)	0.87 (0.79,0.97)	0.90 (0.81,1.01)	0.83 (0.74,0.92)	0.002	0.96 (0.94,0.99)
Multivariable HR (95%CIs) ^b	1.00 (reference)	0.93 (0.84,1.03)	0.91 (0.82,1.02)	0.95 (0.85,1.06)	0.88 (0.78,0.99)	0.063	0.98 (0.95,1.00)
CVD mortality
No. of deaths	781	549	452	392	312
Crude HR (95%CIs) ^a	1.00 (reference)	0.79 (0.71,0.88)	0.76 (0.68,0.85)	0.76 (0.67,0.85)	0.70 (0.61,0.80)	<0.001	0.92 (0.89,0.95)
Multivariable HR (95%CIs) ^b	1.00 (reference)	0.82 (0.73,0.91)	0.83 (0.74,0.94)	0.85 (0.75,0.96)	0.80 (0.70,0.92)	0.001	0.95 (0.92,0.98)
Stroke mortality
No. of deaths	426	271	245	221	154
Crude HR (95%CIs) ^a	1.00 (reference)	0.71 (0.61,0.83)	0.75 (0.64,0.88)	0.78 (0.66,0.91)	0.63 (0.52,0.76)	<0.001	0.91 (0.88,0.95)
Multivariable HR (95%CIs) ^b	1.00 (reference)	0.75 (0.64,0.87)	0.84 (0.71,0.98)	0.87 (0.74,1.03)	0.72 (0.59,0.86)	0.006	0.94 (0.91,0.98)
CHD mortality
No. of deaths	132	98	75	65	60
Crude HR (95%CIs) ^a	1.00 (reference)	0.83 (0.64,1.08)	0.75 (0.56,0.99)	0.75 (0.55,1.01)	0.81 (0.60,1.11)	0.07	0.94 (0.87,1.01)
Multivariable HR (95%CIs) ^b	1.00 (reference)	0.85 (0.65,1.11)	0.81 (0.61,1.08)	0.83 (0.61,1.13)	0.91 (0.66,1.24)	0.351	0.97 (0.90,1.04)
AMI mortality
No. of deaths	89	66	50	48	41
Crude HR (95%CIs) ^a	1.00 (reference)	0.85 (0.61,1.17)	0.75 (0.53,1.07)	0.82 (0.58,1.17)	0.81 (0.56,1.18)	0.200	0.95 (0.87,1.03)
Multivariable HR (95%CIs) ^b	1.00 (reference)	0.88 (0.64,1.22)	0.82 (0.58,1.17)	0.92 (0.64,1.31)	0.91 (0.62,1.33)	0.589	0.98 (0.90,1.06)

Abbreviation: Q, quintiles; SWHS, Shanghai Women’s Health Study; HR, hazards ratio; CI, confidence interval; CVD, cardiovascular disease; CHD, coronary artery heart disease; AMI, acute myocardial infarction.

Crude HR: Adjusted for age at baseline, energy intake.

Multivariable HR: Additionally adjusted for education, income, occupation, smoke, alcohol, body mass index, waist-hip ratio, physical activity, history of diabetes, hypertension, coronary heart disease and stroke, vitamin B supplements use, menopausal status, and hormone replacement therapy.