Table 4.
Subgroup analysis of association of energy-adjusted dietary vitamin B6 intake with all-cause mortality in SMHS (2002–2014)
| Quintiles of dietary vitamin B6 intake a |
|||||||
|---|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | Q5 | P for trend | P for interaction | |
| Age at baseline | 0.459 | ||||||
| Age <60 y | |||||||
| No. of deaths | 270 | 234 | 245 | 235 | 233 | ||
| HR (95%CIs) | 1.00 (reference) | 0.89 (0.74,1.06) | 0.94 (0.79,1.12) | 0.88 (0.74,1.06) | 0.85 (0.71,1.01) | 0.091 | |
| Age>=60 y | |||||||
| No. of deaths | 1153 | 993 | 839 | 803 | 700 | ||
| HR (95%CIs) | 1.00 (reference) | 0.83 (0.76,0.91) | 0.80 (0.73,0.87) | 0.82 (0.75,0.90) | 0.82 (0.74,0.90) | <0.001 | |
| Smoke status | 0.798 | ||||||
| Never smoker | |||||||
| No. of deaths | 371 | 371 | 334 | 342 | 333 | ||
| HR (95%CIs) | 1.00 (reference) | 0.88 (0.76,1.01) | 0.78 (0.67,0.91) | 0.79 (0.68,0.92) | 0.86 (0.74,1.01) | 0.046 | |
| Ever smoker | |||||||
| No. of deaths | 1052 | 856 | 750 | 696 | 600 | ||
| HR (95%CIs) | 1.00 (reference) | 0.83 (0.76,0.91) | 0.84 (0.77,0.93) | 0.85 (0.77,0.94) | 0.81 (0.73,0.90) | <0.001 | |
| Alcohol use | 0.731 | ||||||
| Never use | |||||||
| No. of deaths | 952 | 808 | 689 | 637 | 573 | ||
| HR (95%CIs) | 1.00 (reference) | 0.86 (0.78,0.94) | 0.83 (0.75,0.91) | 0.80 (0.72,0.89) | 0.84 (0.75,0.93) | <0.001 | |
| Ever use | |||||||
| No. of deaths | 471 | 419 | 395 | 401 | 360 | ||
| HR (95%CIs) | 1.00 (reference) | 0.81 (0.71,0.93) | 0.81 (0.70,0.93) | 0.87 (0.76,1.00) | 0.80 (0.70,0.92) | 0.017 | |
| Body mass index | 0.294 | ||||||
| BMI<24 kg/m2 | |||||||
| No. of deaths | 801 | 714 | 593 | 556 | 438 | ||
| HR (95%CIs) | 1.00 (reference) | 0.86 (0.78,0.95) | 0.80 (0.72,0.89) | 0.82 (0.73,0.91) | 0.80 (0.71,0.90) | <0.001 | |
| BMI>=24 kg/m2 | |||||||
| No. of deaths | 622 | 513 | 491 | 482 | 495 | ||
| HR (95%CIs) | 1.00 (reference) | 0.81 (0.72,0.92) | 0.84 (0.75,0.95) | 0.84 (0.74,0.95) | 0.85 (0.76,0.96) | 0.04 | |
| Energy intake | 0.036 | ||||||
| <Median | |||||||
| No. of deaths | 731 | 814 | 733 | 652 | 450 | ||
| HR (95%CIs) | 1.00 (reference) | 0.77 (0.69,0.85) | 0.77 (0.69,0.85) | 0.77 (0.69,0.86) | 0.74 (0.66,0.84) | <0.001 | |
| >=Median | |||||||
| No. of deaths | 692 | 413 | 351 | 386 | 483 | ||
| HR (95%CIs) | 1.00 (reference) | 0.95 (0.84,1.07) | 0.88 (0.77,1.00) | 0.91 (0.80,1.04) | 0.92 (0.81,1.03) | 0.133 | |
| History of main chronic disease | 0.048 | ||||||
| No | |||||||
| No. of deaths | 995 | 815 | 717 | 688 | 621 | ||
| HR (95%CIs) | 1.00 (reference) | 0.84 (0.76,0.92) | 0.79 (0.72,0.87) | 0.80 (0.73,0.89) | 0.78 (0.70,0.86) | <0.001 | |
| Yes | |||||||
| No. of deaths | 428 | 412 | 367 | 350 | 312 | ||
| HR (95%CIs) | 1.00 (reference) | 0.86 (0.75,0.98) | 0.88 (0.76,1.01) | 0.90 (0.78,1.04) | 0.92 (0.79,1.07) | 0.496 | |
| Vitamin B supplements use | 0.921 | ||||||
| No | |||||||
| No. of deaths | 1284 | 1081 | 939 | 874 | 763 | ||
| HR (95%CIs) | 1.00 (reference) | 0.84 (0.77,0.91) | 0.82 (0.75,0.89) | 0.83 (0.76,0.91) | 0.83 (0.75,0.91) | <0.001 | |
| Yes | |||||||
| No. of deaths | 139 | 146 | 145 | 164 | 170 | ||
| HR (95%CIs) | 1.00 (reference) | 0.86 (0.68,1.09) | 0.82 (0.65,1.04) | 0.82 (0.65,1.04) | 0.84 (0.67,1.07) | 0.228 | |
Abbreviation: Q, quintiles; SMHS, Shanghai Men's Health Study; HR, hazards ratio; CI, confidence interval.
a
HR: Adjusted for age, energy intake, education, income, occupation, smoke, alcohol, body mass index, waist-hip ratio, physical activity, history of diabetes, hypertension, coronary heart disease and stroke, vitamin B supplements use.