FIGURE 1.

Proportion of patients in each risk stratum at baseline and follow-up receiving a) riociguat and b) placebo in PATENT-1, and receiving c) riociguat and d) placebo in CHEST-1, according to the three abbreviated versions of the European Society of Cardiology (ESC)/European Respiratory Society (ERS) risk stratification model. Data may not add up to 100% due to rounding. Only patients who participated in PATENT-2 and CHEST-2 were included in the analysis. The analysis is based on observed data with no imputation. French registry invasive method: number of low-risk criteria fulfilled: 6-min walk distance (6MWD) >440 m, World Health Organization (WHO) functional class (FC) I/II, right atrial pressure (RAP) <8 mmHg and cardiac index ≥2.5 L·min⁻¹·m⁻². French registry non-invasive method: number of low-risk criteria fulfilled: 6MWD >440 m, WHO FC I/II and N-terminal pro-brain natriuretic peptide (NT-proBNP) <300 pg·mL⁻¹. Swedish/COMPERA method: mean of grades (1–3: low, intermediate, high) of six available criteria (6MWD, WHO FC, NT-proBNP, RAP, cardiac index and mixed venous oxygen saturation) as defined in the ESC/ERS 2015 treatment guidelines, rounded to the nearest integer.