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. Author manuscript; available in PMC: 2019 Jun 5.
Published in final edited form as: Ann Neurol. 2015 Nov 13;78(6):1000–1004. doi: 10.1002/ana.24515

Figure 2.

Figure 2

A) Analysis of cell free circulating mtDNA (ccf-mtDNA) in CSF, analysed using two mtDNA targets: MTND1 and MTDN4 showing mean mtDNA copy number per microliter CSF (with 95% CI) for PD cases at t=0 /t=18 months (shaded) and matched controls (unshaded). Asterisks indicate statistical significance (***P=10-3 and ***P=10-4). B) Receiver operating characteristic curve analysis of MTND1 (dotted line) and MTND4 (solid line) calculated ccf-mtDNA; where area under curve (AUC) =0.81 =0.84 and P=2x10-2 P=1x10-2, respectively. Dashed line indicates reference line.