Table 1.
Comparative statistical analysis of ccf-mtDNA copy-number in PD cases to (A) age, gender and age of onset, (B) assessments of cognitive function (Montreal cognitive assessment score (MoCA), the mini-mental state examination score (MMSE) the unified Parkinson's disease rating scale (UPDRS), mild cognitive impairment (MCI), cognitively normal (CN),power of attention (PoA), pattern recognition memory (PRM),spatial recognition Memory (SRM)), (C) assessments of PD/dementia markers (stratified ‘postural instability gait difficulty’/’tremor dominant’ or (PIGD v TD), CSF-total tau (CSF-ttau), CSF-phosphorylated tau (CSF-ptau) and CSF alpha synuclein (CSF-α-synuclein) concentrations) and (D) MAPT and APOE genotypes.
| t=0 months | t=18 months | ||||
|---|---|---|---|---|---|
| Variable | MTND1 (P) | MTND4 (P) | MTND1 (P) | MTND4 (P) | |
| (A) | Age** | 9.00x10-2 | 1.70x10-1 | 6.44x10-1 | 8.48x10-1 |
| Gender* | 9.00x10-1 | 9.11x10-1 | 8.17x10-1 | 9.26x10-1 | |
| Age of Onset** | 1.67x10-1 | 2.11x10-1 | 3.14x10-1 | 3.01x10-1 | |
| (B) | MoCa** | 2.84x10-1 | 3.90x10-1 | 4.72x10-1 | 4.52x10-1 |
| MMSE** | 2.73x10-1 | 3.39x10-1 | 8.67x10-1 | 9.43x10-1 | |
| UPDRSII (on)** | 3.77x10-1 | 4.68x10-1 | 2.57x10-1 | 6.51x10-1 | |
| UPDRSIII (on)** | 4.22x10-1 | 9.97x10-1 | 7.57x10-1 | 8.19x10-1 | |
| MCI v CN* | 5.97x10-1 | 3.09x10-1 | 1.75x10-1 | 1.21x10-1 | |
| POA** | 6.93x10-1 | 4.67x10-1 | 4.39x10-1 | 4.37x10-1 | |
| PRM** | 6.98x10-1 | 7.77x10-1 | 1.77x10-1 | 1.18x10-1 | |
| SRM** | 7.41x10-1 | 6.32x10-1 | 5.93x10-1 | 5.45x10-1 | |
| (C) | PIGD v TD* | 8.20 x10-2 | 7.30x10-2 | 6.18x10-1 | 6.83x10-1 |
| CSF-ttau (pg/ml)** | 9.69x10-1 | 8.95x10-1 | - | - | |
| CSF-ptau (pg/ml)** | 5.33x10-1 | 8.04x10-1 | - | - | |
| CSF-α-synuclein (pg/ml) ** | 1.03x10-1 | 1.64x10-1 | - | - | |
| (D) | MAPT*** | 8.80x10-2 | 5.40x10-2 | 7.26x10-2 | 4.89x10-2 |
| APOE*** | 8.44x10-1 | 7.20x10-1 | 8.41x10-2 | 8.21x10-2 | |
Where * is testing by Mann-Whitney U of mtDNA copy-number versus binary variable, ** is testing by Spearman correlation of mtDNA copy-number versus linear variable and *** is ANOVA testing of